Talma Brenner Selected Research

4- (4- bromophenyl)- 3a,4,5,9b- tetrahydro- 3H- cyclopenta(c)quinoline- 8- sulfonamide

4/2021

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.

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Talma Brenner Research Topics

Disease

16	Myasthenia Gravis 01/2020 - 02/2003
12	Inflammation (Inflammations) 06/2020 - 01/2003
11	Neuroinflammatory Diseases 10/2021 - 03/2006
10	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2021 - 01/2003
6	Multiple Sclerosis 04/2021 - 09/2007
6	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 08/2015 - 05/2006
5	Nervous System Diseases (Neurological Disorders) 01/2020 - 04/2006
5	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 01/2008
4	Alzheimer Disease (Alzheimer's Disease) 10/2013 - 04/2006
2	Muscle Weakness 01/2018 - 08/2015
2	Neuromyelitis Optica (Devic's Disease) 01/2018 - 12/2011
1	Infections 12/2018
1	Paralysis (Palsy) 01/2018
1	Epilepsy (Aura) 10/2013
1	Stroke (Strokes) 10/2013
1	Traumatic Brain Injuries (Traumatic Brain Injury) 10/2013
1	Thymoma (Thymic Carcinoma) 07/2013
1	Disease Progression 03/2013
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2008
1	Muscular Atrophy (Muscle Atrophy) 08/2006
1	Neuromuscular Junction Diseases 02/2003

Drug/Important Bio-Agent (IBA)

7	Cholinergic Agents (Cholinergics)IBA 04/2021 - 04/2006
6	Cholinergic ReceptorsIBA 01/2018 - 02/2003
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2003
5	AntibodiesIBA 08/2015 - 03/2010
4	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2021 - 01/2016
3	AcetylcholinesteraseIBA 10/2012 - 02/2003
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 10/2008 - 09/2007
3	Intravenous Immunoglobulins (IVIG)FDA Link 02/2008 - 01/2008
2	Plasminogen Activators (Plasminogen Activator)IBA 01/2020 - 10/2013
2	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2020 - 08/2014
2	AntigensIBA 12/2018 - 07/2013
2	Immunoglobulin G (IgG)IBA 01/2018 - 03/2010
2	Aquaporin 4IBA 01/2018 - 12/2011
2	AutoantibodiesIBA 01/2018 - 07/2013
2	Therapeutic UsesIBA 01/2017 - 01/2008
2	Fibrinolysin FDA Link 08/2014 - 10/2013
2	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2007 - 03/2006
2	EN101IBA 05/2006 - 04/2006
1	4- (4- bromophenyl)- 3a,4,5,9b- tetrahydro- 3H- cyclopenta(c)quinoline- 8- sulfonamideIBA 04/2021
1	Ligand-Gated Ion ChannelsIBA 06/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	MicroRNAs (MicroRNA)IBA 10/2019
1	Peptides (Polypeptides)IBA 01/2018
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2017
1	ConnectinIBA 07/2013
1	Muscle Proteins (Muscle Protein)IBA 07/2013
1	Phosphotransferases (Kinase)IBA 07/2013
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 03/2013
1	AutoantigensIBA 12/2011
1	Glatiramer Acetate (Copaxone)FDA Link 03/2010
1	Nicotine FDA Link 11/2009
1	Rivastigmine (Exelon)FDA LinkGeneric 10/2008
1	cytisineIBA 09/2007
1	Pharmaceutical PreparationsIBA 01/2007
1	myasthenia gravis anti-skeletal muscle antibody (ASMA)IBA 08/2006
1	muskIBA 08/2006
1	OligodeoxyribonucleotidesIBA 04/2006
1	Messenger RNA (mRNA)IBA 04/2006
1	DNA (Deoxyribonucleic Acid)IBA 03/2006
1	Myelin-Oligodendrocyte GlycoproteinIBA 03/2005
1	Secretory Phospholipases A2IBA 12/2003
1	Phospholipase A2 InhibitorsIBA 12/2003
1	LipopolysaccharidesIBA 12/2003
1	Dinoprostone (PGE2)FDA Link 12/2003
1	heparanaseIBA 01/2003
1	Tyrosine (L-Tyrosine)FDA Link 01/2003
1	2-(4-hydroxyphenoxy)acetic acid-formaldehyde polymerIBA 01/2003
1	Heparin (Liquaemin)FDA LinkGeneric 01/2003
1	AnticoagulantsIBA 01/2003

Therapy/Procedure

3	Immunomodulation 01/2020 - 10/2008
1	Precision Medicine 10/2019
1	Therapeutics 09/2008
1	Plasma Exchange 08/2006